tag:blogger.com,1999:blog-61710846569702372162024-03-19T16:44:10.180-03:00HISTÓRIA DA INSULINAPedro Cavalcantehttp://www.blogger.com/profile/15367908941105629332noreply@blogger.comBlogger13125tag:blogger.com,1999:blog-6171084656970237216.post-23972678467744569872009-08-29T09:29:00.002-03:002009-08-29T09:31:58.267-03:00FimO Blog estará apartir de de hoje desativado. Caso algum leitor queira entrar em contato, favor deixar um comentário.<br />ObrigadoWallace Stwart C. Padilhahttp://www.blogger.com/profile/07757751516224716512noreply@blogger.com2tag:blogger.com,1999:blog-6171084656970237216.post-1823783218012875602009-07-02T23:16:00.003-03:002009-07-02T23:32:41.462-03:00Alternativa à insulina. Coisa do futuro?<a href="http://1.bp.blogspot.com/_lkaer5KW9k4/SZG4rsxLj0I/AAAAAAAAABI/5nISU9dCUV4/s320/insulina.jpg"><img style="margin: 0px 10px 10px 0px; float: left; width: 260px; height: 256px;" alt="" src="http://1.bp.blogspot.com/_lkaer5KW9k4/SZG4rsxLj0I/AAAAAAAAABI/5nISU9dCUV4/s320/insulina.jpg" border="0" /></a><br /><div>A ciência avançou muito nesses quase 100 anos desde que houve os estudos de Paulescu e Banting. Atualmente o tratamento de diabéticos tem surpreendido cada vez mais a sociedade por possibilitar maior inserção social e menos transtornos ao portador dessa doença, aumentando sua qualidade de vida.<br />No Canadá, alguns diabéticos não têm de se preocupar mais com as injeções e agulhas. Qual a solução miraculosa? Uso de pílulas. A partir de estudos realizados pela Universidade Mc Gill, descobriu-se que em um pequeno grupo de portadores de diabetes tipo I no qual há mutações no gene que controla a glicemia, medicação oral trabalha melhor do que a injeção. Este projeto denominado “gene -screening” tem feito estudos no DNA de 1000 diabéticos tipo I procurando ver como muitos têm as mutações. Os médicos pretendem, se esse projeto for bem sucedido, expandi-lo para 100.000 canadenses que têm o tipo I ou diabetes juvenil e que ainda necessitam de injeções diárias de insulina.<br />Surpreendente foi uma adolescente da cidade de Quebec, que diagnosticada com diabetes juvenil ao nascer, parou suas injeções diárias de insulina após os médicos da Universidade descobriram que ela era afetada por uma mutações do gene. Agora ela toma sulfonylurea, que é tomada oralmente.<br /><span style="font-weight: bold;"><br />O que essa droga faz?</span><ul><li>Ela estimula o pâncreas então ele funciona normalmente.</li></ul><span style="font-weight: bold;">Quais as vantagens da droga?</span><br /><ul><li>Não há todo aquele dispendioso trabalho com a seringa, nem risco de hipoglicemia, nem controle ruim dos açúcares do sangue.</li><li>As pessoas podem ter um controle da taxa de glicemia normal, ou seja, se lembrarem de tomar as pílulas, podem comer o que quiserem. Isso é um grande avanço no aumento da qualidade de vida do paciente.</li></ul>Finalmente, através da pesquisas, suspeita-se que uma pequena porcentagem do diabetes tipo I tem causa genética. Quem sabe que mais o futuro (se é que existe futuro?!) está reservando àqueles que sofrem não só do diabetes mas de outras patologias também? E quanto à insulina? Será substituída no tratamento dos diabéticos? Só o tempo dirá.</div><br /><div></div><br /><div>REFERÊNCIAS BIBLIOGRÁFICAS:</div><br /><div><a href="http://www2.canada.com/montreal/montrealgazette/news/story.html?id=8176ae31-af6b-40da-b0ec-5edce3540871">http://www2.canada.com/montreal/montrealgazette/news/story.html?id=8176ae31-af6b-40da-b0ec-5edce3540871</a></div><br /><div></div>Luiz Guilhermehttp://www.blogger.com/profile/04315929686734346411noreply@blogger.com0tag:blogger.com,1999:blog-6171084656970237216.post-9550614619932792032009-07-02T22:01:00.004-03:002009-07-02T23:37:26.081-03:00Estrutura e Ação da InsulinaApós os trabalhos de Dorothy,utilizando raios X para decifrar a estrutura da insulina e Sanger,com seus trabalhos relativos ao sequenciamento dos aminoácidos, a estrutura da proteína estava completamente determinada. Contando com duas subunidades, com três estruturas α-hélice e duas pontes dissulfeto, a insulina foi descrita como uma proteína com predominância de aminoácidos polares e cuja atividade é expressa em monômeros (apesar da capacidade da insulina de se associar a dois íons Zinco formando hexâmeros). Nada a ser questionado.<br />Mas quais são os mecanismos de ação de nossa proteína bi-Nobel? Por ser uma proteína cuja função é diminuir a glicemia sanguínea e estimular o consumo de glicose, a insulina pode ser considerada um fator de crescimento. Como tal, ela se associa a "receptores com tirosina quinase" (RTK, curioso caso de proteína sinalizadora e quinase ao mesmo tempo, provavelmente porque seus genes codificantes se fundiram ao longo da evolução) da membrana plasmática, ativando uma cascata de reações que envolvem a fosforilação de diversas outras enzimas. Dentre essas enzimas, está a proteína fosfatase 1 (PP1) cuja função é a síntese de glicogênio.Pedro Arthurhttp://www.blogger.com/profile/18291415503548023891noreply@blogger.com1tag:blogger.com,1999:blog-6171084656970237216.post-3531212997068361252009-07-02T21:30:00.003-03:002009-07-02T21:47:27.365-03:00O trabalho de Dorothy Hodgkin<a href="http://www2.chemistry.msu.edu/Portraits/images/hodgkins2c.jpg"><img style="FLOAT: left; MARGIN: 0px 10px 10px 0px; WIDTH: 290px; CURSOR: hand; HEIGHT: 383px" alt="" src="http://www2.chemistry.msu.edu/Portraits/images/hodgkins2c.jpg" border="0" /></a><br /><div>Dorothy Hodgkin foi uma brilhante cientista britânica na área da química. Suas pesquisas revolucionaram o mundo da ciência e deram um novo olhar e uma nova perspectiva para os próximos que viriam. Mas, como foi o trabalho de Dorothy?<br />O trabalho de Hodgkin foi centrado na área de cristalografia de raios X. Esse método permitia a determinação da estrutura de proteínas.<br />Dorothy teve seu primeiro contato com a insulina em 1934 quando Robert Robinson lhe ofereceu uma pequena amostra cristalina do hormônio. Dorothy ficou intrigada com aquele hormônio, contudo não se conhecia muito sobre sua estrutura, pois naquela época a cristalografia de raios X ainda não havia se desenvolvido bem. Somente em 1969 (35 anos depois), a elucidação da estrutura espacial da insulina foi alcançada, sendo relatada por Dorothy como sua maior conquista.<br />Dorothy foi brilhante em seu trabalho sendo citada como uma das mais importantes mulheres do século XX. Seu trabalho fascinante prosseguia decifrando a estrutura atômica de uma substância após a outra, sendo a sucessora mais complexa que sua precedente. Em plena Segunda Guerra Mundial, Dorothy decifrou a estrutura da penicilina. Logo após veio a estrutura da vitamina B12(que lhe rendeu o Nobel), a cura da anemia perniciosa e logo após a estrutura do diabetes que ajudou bastante no tratamento dos diabéticos. Com sua determinação implacável e imaginação brilhante desenvolveu a cristalografia como qualquer outro cientista jamais houvera conseguido.<br />Por fim, o trabalho de Dorothy culminou em descobertas ainda maiores. A elucidação da estrutura da molécula de DNA por seus sucessores ajudou a compreender melhor a função dessa molécula biológica que regula todo o processo metabólico celular e, por conseguinte, do organismo.<br /><br />REFERÊNCIAS BIBLIOGRÁFICAS<br />http://en.wikipedia.org/wiki/Dorothy_Crowfoot_Hodgkin<br /><br />Se for de seu desejo saber como funciona simplificadamente a cristalografia: http://books.google.com.br/books?id=p4XSGPTzV_kC&pg=PA235&lpg=PA235&dq=dOROTHY+HODGKIN&source=bl&ots=qaw5VS1D4Q&sig=KWHzQCxBtVhkOJDYCcDRzgZaybY&hl=pt-BR&ei=5S49SuzVLcOktgfT1tge&sa=X&oi=book_result&ct=result&resnum=9 -pgs 241,242 e 243</div>Luiz Guilhermehttp://www.blogger.com/profile/04315929686734346411noreply@blogger.com5tag:blogger.com,1999:blog-6171084656970237216.post-1962487345904733322009-07-02T18:43:00.005-03:002009-07-02T23:18:36.517-03:00A Evolução da Insulinoterapia<a onblur="try {parent.deselectBloggerImageGracefully();} catch(e) {}" href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgumJyco9K4U-GHNDHEknPvCuqkPkr9NAkhjd3Yzfw3QHOry_6ohHkjLUR9Dj74Q6cJxXxkLg8RmA6kHcKE6JpETiQsW4HhBhekMxbczSitOZ1w42iGhlf2LD9BkBsyFBMuDIRcDiLvR8_S/s1600-h/seringa2_copy.jpg"><img style="margin: 0pt 10px 10px 0pt; float: left; cursor: pointer; width: 320px; height: 214px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgumJyco9K4U-GHNDHEknPvCuqkPkr9NAkhjd3Yzfw3QHOry_6ohHkjLUR9Dj74Q6cJxXxkLg8RmA6kHcKE6JpETiQsW4HhBhekMxbczSitOZ1w42iGhlf2LD9BkBsyFBMuDIRcDiLvR8_S/s320/seringa2_copy.jpg" alt="" id="BLOGGER_PHOTO_ID_5353985474734318082" border="0" /></a><br /><span style="font-family:arial;">O tratamento do quadro de Diabetes Mellitus através de injeções contendo insulina sofreu várias mudanças desde sua descoberta. As primeiras aplicações datam da década de 20, como já foi dito aqui no blog. Naquela época foi comprovada a alta eficiência da aplicação da insulina em pacientes que já se encontravam em um nível clínico deteriorado. Estes apresentaram aumento drástico na expectativa de vida.</span><br /><br /><span style="font-family:arial;">Porém, àquela época, o tratamento era feito com insulina de ação rapida, o que obrigava ao paciente fazer várias aplicações durante o dia, o que gerou muitas reclamacões. A partir daí, a comunidade científica e a industria farmacêutica se engajaram na procura de formas de melhorar o tratamento, por exemplo, aumentando o tempo de ação das insulinas.</span><br /><span style="font-family:arial;">Entre as décadas de 30 e 40, foi descoberto que quando adicionada protamina à molécula de insulina, seu efeito era prolongado.<br />Esta descoberta gerou a Insulina NPH, que é considerada de média duração. Também por volta da mesma época, adicionou-se zinco à molécula, formando a então </span><span style=";font-family:Verdana,Arial,Helvetica,sans-serif;font-size:100%;" ><span style=";font-family:arial;font-size:85%;" >Protamine-Zinc Insulin (PZI)</span><span style="font-family:arial;">. Nos anos seguintes, estas insulinas dominaram o mercado mundial, apesar de ainda apresentaram muitos problemas, principalmente relacionados à resistência imunológica à insulina.<br /><br />A partir da década de 70, fruto dos enormes avanços na biologia, foi dado início à era das insulinas biossintéticas humanas. Estas tinham absorção mais rápida e já não apresentavam problemas de reações alérgicas. Dos últimos 15 anos para cá, tem surgido importantes análogos à insulina, como o lispro, a glargina e a glulisina. Uma maior variedade de insulina possibilita um maior controle dos índices glicêmicos, uma vez que o tratamento atual pode se adequar ao metabolismo do paciente, ou seja, é possível a administração de misturas de diferentes insulinas para ter certeza que a resposta será como esperada.<br /><br />Fonte - Scielo Brasil:<br /><br /></span></span>PIRES, Antonio Carlos; CHACRA, Antonio Roberto. A evolução da insulinoterapia no diabetes melito tipo 1.<b> Arq Bras Endocrinol Metab</b>, São Paulo, v. 52, n. 2, Mar. 2008 . Available from <http://www.scielo.br/scielo.php?script=sci_arttext&pid=s0004-27302008000200014&lng=en&nrm=iso>. access on02 July 2009. doi: 10.1590/S0004-27302008000200014.Pedro Cavalcantehttp://www.blogger.com/profile/15367908941105629332noreply@blogger.com1tag:blogger.com,1999:blog-6171084656970237216.post-80297586313982453712009-06-30T19:44:00.004-03:002009-06-30T23:56:05.890-03:00Os trabalhos de Sanger molécula de insulina<a onblur="try {parent.deselectBloggerImageGracefully();} catch(e) {}" href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEivCda4mIhzCvvF6VaOdtTHtNpgCBwuCuNeWOZsIxkXNsyfIYToaoX-xPhfE2Yvr0geXxoLwjgv3lAdF9MhXyRhaP0X5S6lkK7jazxGVSjaxHdfsQtr4SkZ-7JBg35S4j_dxna2tdmt4_I/s1600-h/225px-Frederick_Sanger2.jpg"><img style="margin: 0pt 0pt 10px 10px; float: right; cursor: pointer; width: 225px; height: 277px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEivCda4mIhzCvvF6VaOdtTHtNpgCBwuCuNeWOZsIxkXNsyfIYToaoX-xPhfE2Yvr0geXxoLwjgv3lAdF9MhXyRhaP0X5S6lkK7jazxGVSjaxHdfsQtr4SkZ-7JBg35S4j_dxna2tdmt4_I/s320/225px-Frederick_Sanger2.jpg" alt="" id="BLOGGER_PHOTO_ID_5353257681855583970" border="0" /></a><span style="font-size:100%;">
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mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; text-indent:18.0pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Times New Roman","serif"; mso-ascii-font-family:"Times New Roman"; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:"Times New Roman"; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} </style> <![endif]--> <p class="MsoNormal" style="text-indent: 17.85pt; line-height: 150%; font-family: times new roman; text-align: justify;"><span style="line-height: 150%;font-size:100%;" >A seqüência de aminoácidos da insulina foi descrita por Frederick Sanger em 1953. Esse evento foi um marco histórico, uma vez que essa foi a primeira seqüência de aminoácidos a ser descrita, e através da qual pôde se concluir que cada proteína tem uma seqüência de aminoácidos única e específica. Isso rendeu a Sanger o prêmio Nobel de 58.<o:p></o:p></span></p><div> </div><p class="MsoNormal" style="text-indent: 17.85pt; line-height: 150%; text-align: left;font-family:times new roman;"><span style="line-height: 150%;font-size:100%;" >O método utilizado por Sanger consistia em marcar o aminoácido N-terminal da molécula de insulina com 2,4 dinitrofluorobenzeno. Após um tratamento de fragmentação da proteína, o aminoácido N-terminal marcado pode ser analisado e identificado. O aparecimento de duas moléculas N-terminal permitiu concluir que a insulina é formada por duas cadeias polipeptídicas, as quais puderam ser separadas e estudadas. Entretanto, de nada serve a identificação isolada do aminoácido N-terminal. Para identificar os outros aminoácidos, Sanger utilizou da clivagem da proteína, gerando vários fragmentos peptídicos e através da analise dos diferentes grupos N-terminal, identificando os aminoácidos.Para manter a seqüência de proteínas após a fragmentação e para separar os diferentes fragmentos, montava-se um mapa de peptídeos (em uma folha que ocorria eletroforese em um eixo, e cromatografia em outro, montando um gráfico cujos pontos de diferentes coordenadas identificava diferentes fragmentos de proteína). Para identificar todas os aminoácidos, diferentes tipos de clivagem foram aplicados. Após identificar as seqüências, Sanger, com ajuda de outros pesquisadores, identificou os elos entre as cadeias na forma de pontes dissulfeto.<o:p></o:p></span></p><div style="text-align: left;"> </div><p class="MsoNormal" style="text-indent: 17.85pt; line-height: 150%; text-align: left;font-family:times new roman;"><span style="line-height: 150%;font-size:100%;" >Como informado acima, insulina é formada por duas cadeias de aminoácidos, que juntas somam 51 aminoácidos, sendo uma das moléculas protéicas mais simples que se conhece (fato que provavelmente contribuiu para sua descoberta pioneira).A cadeia A possui 21 aminoácidos e a cadeia B possui 30. Essas cadeias são unidas por duas ligações dissulfeto entre A7 Cys e B7 Cys, e A20 Cys e B19 Cys (considere A como a primeira cadeia e B como a segunda; 7,19 e 20 como as posições dos aminoácidos nas cadeias lidas de N-terminal a C-terminal; e Cys de acordo com a abreviatura oficial de aminoácidos em língua inglesa) . Além disso, uma ligação dissulfeto é estabelecida entre A6 Leu e A11 Leu. A seqüência e apresentada a seguir:</span></p><p class="MsoNormal" style="text-indent: 17.85pt; line-height: 150%; font-family: times new roman; text-align: left;"><span style="font-size:100%;">
<br /></span><span style="line-height: 150%;font-size:100%;" ><o:p></o:p></span></p><div style="text-align: left;"> </div><p class="MsoNormal" style="text-indent: 17.85pt; line-height: 150%; font-family: times new roman; text-align: left;"><span style="line-height: 150%;font-size:100%;" ><o:p> </o:p></span></p><div style="text-align: left;"> </div><p style="font-family: times new roman; text-align: left;" class="MsoNormal"><span style="font-size:100%;">Cadeia A (21residuos de aminoácidos):<o:p></o:p></span></p><div style="text-align: left;"> </div><p class="MsoNormal" style="margin-right: 8.5pt; text-indent: 17.85pt; line-height: 150%; font-family: times new roman; text-align: left;"><span style="font-size:100%;">N-terminal </span><span style="font-size:100%;">GLY ILE VAL GLU GLN CYS CYS THR SER ILE CYS LEU TYR GLN LEU GLU ASN TYR CYS ASN C-terminal</span></p><p class="MsoNormal" style="margin-right: 8.5pt; text-indent: 17.85pt; line-height: 150%; font-family: times new roman; text-align: left;"><span style="font-size:100%;">
<br /></span><span style="font-size:100%;"><o:p></o:p></span></p><div style="text-align: left;"> </div><p style="font-family: times new roman; text-align: left;" class="MsoNormal"><span style="font-size:100%;"><o:p> </o:p></span></p><div style="text-align: left;"> </div><p style="font-family: times new roman; text-align: left;" class="MsoNormal"><span style="font-size:100%;">Cadeia B (30 resíduos de aminoácidos):<o:p></o:p></span></p><div style="text-align: left;"> </div><p class="MsoNormal" style="margin-right: 8.5pt; text-indent: 17.85pt; line-height: 150%; font-family: times new roman; text-align: left;"><span style="font-size:100%;">N-terminal PHE VAL ASN GLN HIS LEU CYS GLY ASP HIS LEU VAL GLU ALA LEU TYR LEU VAL CYS GLY GLU ARG GLY PHE PHE TYR THR PRO LYS THR C-terminal</span></p><p class="MsoNormal" style="margin-right: 8.5pt; text-indent: 17.85pt; line-height: 150%; font-family: times new roman; text-align: left;"><span style="font-size:100%;">
<br /></span><span style="font-size:100%;"><o:p></o:p></span></p><div style="text-align: left;"> </div><p class="MsoNormal" style="margin-right: 8.5pt; text-indent: 17.85pt; line-height: 150%; font-family: times new roman; text-align: left;"><span style="font-size:100%;"><o:p> </o:p></span></p><div style="text-align: left;"> </div><p class="MsoNormal" style="text-indent: 17.85pt; line-height: 150%; font-family: times new roman; text-align: left;"><span style="line-height: 150%;font-size:100%;" >Note que as cadeias não começam com Metionina, aminoácido sempre presente no primeiro <i style=""><span style=""> </span>loco </i>da proteína. Isso porque a Insulina e secretada da célula como pré-insulina, sendo reestruturada na matriz extracelular para se tornar ativa.</span></p><p class="MsoNormal" style="text-indent: 17.85pt; line-height: 150%; font-family: times new roman; text-align: left;"><span style="font-size:100%;">A conformação espacial da insulina se dá em duas α-hélices para a cadeia A de A2 Ile a A8 Thr e de A13 Leu a A19 Thr, e uma para a cadeia B de B9 Ser a B19 Cys. Em postagem futura explicaremos a influência da estrutura protéica na atividade enzimática.</span></p><p class="MsoNormal" style="text-indent: 17.85pt; line-height: 150%; font-family: times new roman; text-align: left;"><span style="font-size:100%;">
<br /></span></p><p class="MsoNormal" style="text-indent: 17.85pt; line-height: 150%; font-family: times new roman; text-align: left;"><span style="font-size:100%;">Referências:</span></p><div style="text-align: left;"><meta equiv="Content-Type" content="text/html; charset=utf-8"><meta name="ProgId" content="Word.Document"><meta name="Generator" content="Microsoft Word 12"><meta name="Originator" content="Microsoft Word 12"><link style="font-family: times new roman;" rel="File-List" href="file:///C:%5CUsers%5Cpedro%5CAppData%5CLocal%5CTemp%5Cmsohtmlclip1%5C01%5Cclip_filelist.xml"><link style="font-family: times new roman;" rel="themeData" href="file:///C:%5CUsers%5Cpedro%5CAppData%5CLocal%5CTemp%5Cmsohtmlclip1%5C01%5Cclip_themedata.thmx"><link style="font-family: times new roman;" rel="colorSchemeMapping" href="file:///C:%5CUsers%5Cpedro%5CAppData%5CLocal%5CTemp%5Cmsohtmlclip1%5C01%5Cclip_colorschememapping.xml"><!--[if gte mso 9]><xml> <w:worddocument> <w:view>Normal</w:View> 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150%; font-family: times new roman; text-align: left;"><span style="font-size:100%;">
<br /><span lang="EN-US"><a href="http://www.biotopics.co.uk/as/insulinproteinstructure.html"><span style="line-height: 150%; text-transform: uppercase;font-size:12pt;" lang="PT-BR" ></span></a></span><span style="line-height: 150%; text-transform: uppercase;font-size:12pt;" ><o:p></o:p></span></span></p><p></p><div style="text-align: left;"> <span style="font-family:times new roman;font-size:100%;"><span lang="EN-US" style="font-size:11pt;"><a href="http://www2.iq.usp.br/docente/srmarana/view.pdf?PHPSESSID=3459483c9db8101ec893cc86b3306421"><span style="text-transform: uppercase;font-size:12pt;" lang="PT-BR" >http://www2.iq.usp.br/docente/srmarana/view.pdf?PHPSESSID=3459483c9db8101ec893cc86b3306421</span></a></span></span>
<br /></div><p class="MsoNormal" style="text-indent: 17.85pt; line-height: 150%;"><span style="line-height: 150%;font-size:100%;" ><o:p></o:p></span></p> <span style="line-height: 150%;font-size:12pt;" ><o:p></o:p></span> Pedro Arthurhttp://www.blogger.com/profile/18291415503548023891noreply@blogger.com0tag:blogger.com,1999:blog-6171084656970237216.post-31240625930147869162009-06-23T19:55:00.004-03:002009-07-02T21:45:25.082-03:00A insulina até a década de 60<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiETSNc7mrBF-DrtxjgGwdGgzx28Bvs1mD9oI57aZcqaky7AkBnf5IaiYRkCMHLb-VlsHNDrlCZYk-jK_yWI4W4wCEGTODhm6HMTqoC7Yr-dvGdcA29ncbojlccGZOxEdAvSg78_72PBlA/s320/porco.jpg"><img style="FLOAT: left; MARGIN: 0px 10px 10px 0px; WIDTH: 307px; CURSOR: hand; HEIGHT: 306px" alt="" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiETSNc7mrBF-DrtxjgGwdGgzx28Bvs1mD9oI57aZcqaky7AkBnf5IaiYRkCMHLb-VlsHNDrlCZYk-jK_yWI4W4wCEGTODhm6HMTqoC7Yr-dvGdcA29ncbojlccGZOxEdAvSg78_72PBlA/s320/porco.jpg" border="0" /></a><br /><div><a href="http://www.portalsaofrancisco.com.br/alfa/corpo-humano-sistema-nervoso/imagens/insulina.jpg"></a><div>A insulina, depois do trabalho de Banting, tornava-se a nova arma da medicina para tratar o diabetes. Nos anos posteriores, a dieta de jejum prolongado foi substituída pelas injeções de insulina que melhoravam e muito os sintomas do diabetes. A garota Elizabeth Hughes, em questão de meses, saiu do estado de grande magreza para peso normal. Pôde ver-se crescendo e voltar à escola. Foi visto como um milagre o que aquele líquido fazia.<br />A insulina ainda era tirada de animais como bois e porcos que funcionavam até bem. Contudo, tinha alguns reveses como: não era totalmente compatível com o hormônio humano o que podia causar reações alérgicas e erupções na pele que resultavam em perda de tecido nos locais da injeção.<br />Como isso poderia ser melhorado?<br />Os pesquisadores se debruçaram sobre os livros e com o desenvolvimento de tecnologia cada vez mais avançada puderam estudar esse hormônio cada vez mais profundamente. Agora, todo conhecimento sobre a molécula de insulina seria útil para melhorar o tratamento de diabéticos. Foi exatamente na década de 50 que aconteceu mais uma descoberta envolvendo a insulina que rendeu um Nobel: em 1958, Frederik Sanger, biólogo britânico, determinou a seqüência exata de aminoácidos da molécula de insulina, a estrutura primária, sendo laureado com o Prêmio Nobel de Química. Já na outra década, em 1964 mais precisamente, outro Nobel foi concedido a uma pesquisadora que utiliza a cristalografia de raios X(técnica que permitiu a elucidação da estrutura tridimensional da insulina) em seu trabalho: Dorothy Crowfoot Hodgkin. Tal pesquisadora, formada em química, determinou a conformação espacial da molécula de insulina mediante estudos de difração de raios X. Nessa época(1969) ,Dorothy já havia sido laureada pelo seu trabalho com a vitamina B12 . Em outro post, serão abordados melhor o trabalho de Dorothy e de Sanger que os levaram ao Nobel.<br />Finalmente, nota-se que a insulina é realmente muito importante na história da humanidade. Até os anos 60, mesmo o tratamento utilizado sendo o da injeção de insulina animal no ser humano, salvou-se muitas vidas e melhorou sua qualidade bastante significativamente.<br />Referências bibliográficas:<br /><a href="http://pt.wikipedia.org/wiki/Insulina">http://pt.wikipedia.org/wiki/Insulina</a><br /><a href="http://books.google.com.br/books?id=p4XSGPTzV_kC&pg=PA235&lpg=PA235&dq=dOROTHY+HODGKIN&source=bl&ots=qaw5VS1D4Q&sig=KWHzQCxBtVhkOJDYCcDRzgZaybY&hl=pt-BR&ei=5S49SuzVLcOktgfT1tge&sa=X&oi=book_result&ct=result&resnum=9">http://books.google.com.br/books?id=p4XSGPTzV_kC&pg=PA235&lpg=PA235&dq=dOROTHY+HODGKIN&source=bl&ots=qaw5VS1D4Q&sig=KWHzQCxBtVhkOJDYCcDRzgZaybY&hl=pt-BR&ei=5S49SuzVLcOktgfT1tge&sa=X&oi=book_result&ct=result&resnum=9</a> (pg 261)<br />http://saude.hsw.uol.com.br/insulina-e-diabetes1.htm<br /><br />Sugestão de leitura:<br />http://www.scielo.br/scielo.php?pid=S0004-27302004000200005&script=sci_arttext</div></div>Luiz Guilhermehttp://www.blogger.com/profile/04315929686734346411noreply@blogger.com0tag:blogger.com,1999:blog-6171084656970237216.post-5679490198832391182009-06-23T19:34:00.003-03:002009-06-23T19:51:26.711-03:00Prêmio Nobel de Medicina/Fisiologia de 1923<a href="http://img.photobucket.com/albums/v702/Pinatubo/IgNobelPrize.jpg"><img style="FLOAT: left; MARGIN: 0px 10px 10px 0px; WIDTH: 300px; CURSOR: hand; HEIGHT: 399px" alt="" src="http://img.photobucket.com/albums/v702/Pinatubo/IgNobelPrize.jpg" border="0" /></a><br /><div><span >Não há dúvida do quão importante foram os trabalhos de Nicolae Paulescu e da equipe de Banting que possibilitaram o tratamento de diabéticos por meio de injeções de insulina. Contudo, várias figuras da ciência e até indivíduos que conhecem um pouco da história da insulina já tomaram partido quanto à seguinte questão: É a equipe de Banting a verdadeira merecedora do Nobel de 1923 ou Nicolae Paulescu quem realmente deveria tê-lo recebido? Daqui a alguns anos já será o centenário da entrega desse prêmio e para não deixá-los de fora dessa discussão vamos apontar os pontos de vista de cada um dos lados e você vai poder tirar suas conclusões.<br />.Paulescu foi quem realmente publicou o primeiro trabalho(1921) sobre a diminuição da glicosúria ao se aplicar extratos pancreáticos aquosos em cães. É claro que os primeiros trabalhos sobre esse assunto não foram dele (Zuelzer e Kleiner), contudo ele foi o primeiro a publicar, o que realmente conta oficialmente.<br />.É apontado por muitos como o verdadeiro descobridor da insulina. (Foi de fato reconhecido somente meio século após a primeira patente).<br />Por que o Prêmio Nobel de medicina de 1923 foi então dado a equipe de Banting?<br />.A comissão do Karolinska Institutet, que indica os laureados ao Prêmio Nobel de Medicina, afirmou que a escolha da equipe de Banting como a vencedora se deve ao fato de terem sido eles quem primeiro criaram a extração prática da insulina. No entanto, o que é conhecido pela maioria das pessoas e está até em sites(</span><a href="http://www.nobelpreis.org/portugues/medizin/macleod.htm"><span >http://www.nobelpreis.org/portugues/medizin/macleod.htm</span></a><span >) é que foram agraciados pela descoberta da insulina.<br />Por fim, não é intenção de nenhum componente do grupo tomar partido nessa discussão. Com certeza o prêmio Nobel dado à Banting e Mcleod não foi desmerecido, ora porque o bem que fizeram à humanidade ao possibilitar o tratamento de diabéticos por meio de injeções de insulina é imensurável. O que realmente deve-se parar para pensar é se o Nobel deveria ser pela descoberta da insulina. Contudo, finalmente há de se reconhecer a grande importância de Nicolae na história da insulina, pois foi reconhecido como o descobridor e também um precursor de fundamental importância. Para saber mais sobre a descoberta da insulina leia o livro de Michael Bliss: The Discovery of Insulin.<br />Referências bibliográficas: </span></div><div><a href="http://www.guiadodiabetes.com.br/sp_int2.php?cont=409&ses=81"><span >http://www.guiadodiabetes.com.br/sp_int2.php?cont=409&ses=81</span></a><span ><br /></span><a href="http://pt.wikipedia.org/wiki/Insulina"><span >http://pt.wikipedia.org/wiki/Insulina</span></a><span ><br /></span><a href="http://www.nobelpreis.org/portugues/medizin/macleod.htm"><span >http://www.nobelpreis.org/portugues/medizin/macleod.htm</span></a><span > </span></div>Luiz Guilhermehttp://www.blogger.com/profile/04315929686734346411noreply@blogger.com1tag:blogger.com,1999:blog-6171084656970237216.post-86412445670699885112009-06-21T22:25:00.000-03:002009-07-01T18:58:47.159-03:00Insulina, um anabolizante?Se perguntado aleatoriamente a pessoas sobre o que é a insulina, a grande maioria diria que se trata de um hormônio, e, talvez, uma minoria iria além e acrescentaria que é um hormônio que induz a captação de glicose pelo organismo, diminuindo a glicemia. Porém, a insulina vai muito além disso, contribuindo não só para o status glicêmico do corpo, mas para uma enorme gama de reações metabólicas de cunho anabólico.
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<br /></div>A Insulina é um hormônio peptídico formado por 51 resíduos de aminoácidos e de peso molecular de 5808 Da. Ela é produzida nas células beta (células β) do pâncreas, presentes nas chamadas ilhotas de Langerhans do pâncreas, uma glândula mista localizada posteriormente ao estômago, na cavidade abdominal. A insulina não é exclusividade dos seres humanos, estando presente em outras espécies animais, porém com relativas diferenças estruturais. Sua estrutura receberá atenção maior em postagens futuras.
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<br /><a onblur="try {parent.deselectBloggerImageGracefully();} catch(e) {}" href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgLHUi3g6Nu55yXFNm3dWFhLTy23GhA09ncVDzaUbaiVI6FPqCvIyAau15H70NYrpFUiLBBxTEW7dIioMH4Vn0wqWO3dbAGB-KExXHzvDZBQmoYOv3pLRR34sSf8HfjvKQHtZAhijr5cHNf/s1600-h/post5_1.jpg"><img style="margin: 0px auto 10px; display: block; text-align: center; cursor: pointer; width: 276px; height: 199px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgLHUi3g6Nu55yXFNm3dWFhLTy23GhA09ncVDzaUbaiVI6FPqCvIyAau15H70NYrpFUiLBBxTEW7dIioMH4Vn0wqWO3dbAGB-KExXHzvDZBQmoYOv3pLRR34sSf8HfjvKQHtZAhijr5cHNf/s320/post5_1.jpg" alt="" id="BLOGGER_PHOTO_ID_5349957873261561122" border="0" /></a><div style="text-align: justify;">Os níveis de insulina no sangue variam de forma intermitente, sendo controlados basicamente de acordo com os níveis plasmáticos de glicose. Porém, uma vez liberada em resposta à hiperglicemia, ela atuará amplamente no organismo promovendo anabolismo. As principais ações anabólicas são:
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font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-fareast-language:EN-US;} </style> <![endif]--><span style="line-height: 115%;font-family:";font-size:12;" >Portanto, como vocês podem observar, a insulina pode auxiliar tanto</span><span style="line-height: 115%;font-family:";font-size:12;" > no ganho de massa magra, devido à ótima captação de nutrientes e aceleração na ressíntese tecidual,</span><span style="line-height: 115%;font-family:";font-size:12;" > como também pode ajudar no aumento da gordura corporal.</span>
<br />
<br /><div style="text-align: justify;">Por isso a insulina pode ser considerada um hormônio de características anabólicas. Porém vale ressaltar que tais ações, e a própria liberação de insulina no organismo, só ocorrem se o metabolismo estiver “saciado” de nutrientes, ou mesmo com um excedente nutricional em voga. Logo, se houver qualquer carência energética, os níveis altos de insulina logo serão substituídos por glucagon e quaisquer ações anabólicas serão logo interrompidas.
<br />
<br />Com essa pequena introdução da funcionalidade da insulina, fica claro seu importante papel metabólico, trata-se, sem dúvida, do mais importante hormônio do metabolismo energético.
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table.MsoNormalTable {mso-style-name:"Tabela normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0cm; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-fareast-language:EN-US;} </style> <![endif]--> <p class="MsoNormal"><span style="line-height: 115%;font-family:";font-size:12;" >Auxilio:<o:p></o:p></span></p> <p class="MsoNormal"><a href="http://en.wikipedia.org/wiki/Insulin#Synthesis"><span style="line-height: 115%;font-family:";font-size:12;" >http://en.wikipedia.org/wiki/Insulin#Synthesis</span></a><span style="line-height: 115%;font-family:";font-size:12;" ><o:p></o:p></span></p> <p class="MsoNormal"><a href="http://www.fisiculturismo.com.br/artigo.php?id=217&titulo=Insulina:+entendendo+a+import%C3%A2ncia+desse+horm%C3%B4nio.html"><span style="line-height: 115%;font-family:";font-size:12;" >http://www.fisiculturismo.com.br/artigo.php?id=217&titulo=Insulina:+entendendo+a+import%C3%A2ncia+desse+horm%C3%B4nio.html</span></a></p></div></div>Wallace Stwart C. Padilhahttp://www.blogger.com/profile/07757751516224716512noreply@blogger.com6tag:blogger.com,1999:blog-6171084656970237216.post-85345891300026940402009-06-16T21:45:00.004-03:002009-07-02T23:59:58.001-03:00Ainda na década de 20: Benting, Macleod e Best<a onblur="try {parent.deselectBloggerImageGracefully();} catch(e) {}" href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjqGvjfzkH5zZNMoX_ZEd0v-Yt-7NtV-vqFronSgazPgaaE8J0btw9ibkdwMiqrUrwjvHPncRYNqybBYdbLuoJtZD0UvkJAybBbJQt0xjnRJJYfO7cc8LJFHCma0EZUfY0ugp0Gcvck2L7Y/s1600-h/BanMacBest.jpg"><img style="margin: 0px auto 10px; display: block; text-align: center; cursor: pointer; width: 320px; height: 152px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjqGvjfzkH5zZNMoX_ZEd0v-Yt-7NtV-vqFronSgazPgaaE8J0btw9ibkdwMiqrUrwjvHPncRYNqybBYdbLuoJtZD0UvkJAybBbJQt0xjnRJJYfO7cc8LJFHCma0EZUfY0ugp0Gcvck2L7Y/s320/BanMacBest.jpg" alt="" id="BLOGGER_PHOTO_ID_5348093627124537970" border="0" /></a>Os anos 20 começaram já a todo vapor com a descoberta de Nicolae Paulescu. Mas não se podia parar por ali né?! A ciência tinha de progredir e era isso que ia acontecer.<br /><br />Em 1921, o médico canadense Frederick Banting, já bastante interessado no diabetes e no trabalho de Minkowski, viaja para Toronto a fim de encontrar J.J. Macleod com a idéia de “ligar duto pancreático do cão. Manter cão vivo até que acinos se degenerem, sobrando ilhotas. Tentar isolar solução interna delas e aliviar glicosúria”. A idéia não impressionara muito Macleod, mas mesmo assim Macleod deixou a disposição de Banting um laboratório de sua universidade, e um assistente, Charles Best, naquela época ainda estudante de medicina, e ainda dez cães antes de sair em suas férias de verão.<br /><br />Como consistia o método de Banting e Best?<br /><br />Primeiramente eles amarravam uma ligadura ao redor do ducto pancreático dos cães, e várias semanas depois, examinavam que as células pancreáticas tinham morrido e sido absorvidas pelo sistema imune, deixando milhares de ilhotas. Isolaram a proteína dessas ilhotas para produzir o que vinham chamando de isletina.<br /><br />Macleod retornara da Europa, e agora se mostrava mais curioso com a pesquisa. Assim pediu uma contraprova para saber se o método realmente funcionava. O segundo ensaio funcionara. Em novembro de 1921, Macleod publicou os resultados. Contudo, havia um fator que enrolava o desenvolvimento do trabalho: a demora de seis semanas para retirar a isletina. Brilhantemente, Banting sugeriu que utilizassem pâncreas de bezerro, que ainda não teria desenvolvido enzimas digestivas, o que resultou em sucesso da empreitada.<br /><br /><a onblur="try {parent.deselectBloggerImageGracefully();} catch(e) {}" href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhuSIuUFxNGzNNWufqb_m0X-5faXb-GArtfvQ8YjGtLwVpV9aHTbHgU_wyxkFcVwBjAY588H1L_L5OYPozR9By2GOre5ytHCNd6Qp5BsIKGTKt0f4cP-OTQxagYX1jvSj4v-m7LU-FjCD1x/s1600-h/cachorro_hospital.jpg"><img style="margin: 0pt 10px 10px 0pt; float: left; cursor: pointer; width: 320px; height: 208px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhuSIuUFxNGzNNWufqb_m0X-5faXb-GArtfvQ8YjGtLwVpV9aHTbHgU_wyxkFcVwBjAY588H1L_L5OYPozR9By2GOre5ytHCNd6Qp5BsIKGTKt0f4cP-OTQxagYX1jvSj4v-m7LU-FjCD1x/s320/cachorro_hospital.jpg" alt="" id="BLOGGER_PHOTO_ID_5348091533420336114" border="0" /></a>O próximo passo foi a purificação da proteína. Para essa tarefa foi chamado ,em dezembro de 1921, o bioquímico James Collip. Em 11 de janeiro de 1922, a primeira injeção de insulina foi recebida por um jovem diabético, Leonard Thompson, que, infelizmente, teve uma reação alérgica severa pela impureza do extrato. Injeções adicionais foram canceladas. Após quase uma quinzena de dias com Collip trabalhando arduamente, este consegue melhorar o extrato. Houve uma nova injeção. Sucesso! Não só não houve efeitos colaterais, mas também eliminou os sintomas de diabetes.<br /><br />Durante a primavera de 1922, Best melhorou as técnicas de preparo a ponto de poder extrair grandes quantidades de insulina, embora o extrato ainda permanecesse impuro. Entretanto, com oferta de ajuda de Eli Lilly (indústria farmacêutica estadounidense) o trabalho progrediu ainda mais. Em novembro de 1922, a Eli Lilly conseguiu a produção de grande quantidade de insulina bastante pura, que logo foi lançada no mercado.<br /><br />Em 1923, Banting e Macleod foram agraciados com o prêmio Nobel de Fisiologia/Medicina. Banting acabou dividindo seu prêmio com Best e Macleod com Collip. Outro fato importante foi a venda da patente da insulina à Universidade de Toronto por apenas um dólar.<br />O prêmio Nobel de 1923 ainda causa uma certa polêmica, que será abordada mais adiante no blog.<br /><br /><br />Fontes:<br /><a href="http://pt.wikipedia.org/wiki/Insulina">http://pt.wikipedia.org/wiki/Insulina</a><br /><a href="http://en.wikipedia.org/wiki/Insulin">http://en.wikipedia.org/wiki/Insulin</a>Pedro Cavalcantehttp://www.blogger.com/profile/15367908941105629332noreply@blogger.com1tag:blogger.com,1999:blog-6171084656970237216.post-39684085870722045012009-06-16T21:19:00.008-03:002009-07-02T23:48:30.157-03:00Década de 20: Nicolae Paulescu<a onblur="try {parent.deselectBloggerImageGracefully();} catch(e) {}" href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg1bd1AaxV-dzbMHblxqlwGm20kNFM2aZ4gkd2NVTaDFAGpdAIpejq2u39iQlpoPrKjRfL1GI2gpVI9QQv1q_DfwMlubY3P8gPrxUV1B6wMMS4pEg37o539NdKHaO2N_ybeLB-rcdBjQOKc/s1600-h/Nicolae_Paulescu_-_Foto03.jpg"><img style="margin: 0pt 10px 10px 0pt; float: left; cursor: pointer; width: 171px; height: 244px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg1bd1AaxV-dzbMHblxqlwGm20kNFM2aZ4gkd2NVTaDFAGpdAIpejq2u39iQlpoPrKjRfL1GI2gpVI9QQv1q_DfwMlubY3P8gPrxUV1B6wMMS4pEg37o539NdKHaO2N_ybeLB-rcdBjQOKc/s320/Nicolae_Paulescu_-_Foto03.jpg" alt="" id="BLOGGER_PHOTO_ID_5348086679325331874" border="0" /></a><br /><span style="font-size:100%;"><span style="font-family:arial;">Os pesquisadores se sentiam cada vez mais instigados a estudar e compreender aquela “secreção interna” que Von Mering e Minkowski havia previamente deduzido a existência. O primeiro fato importante surgiu em 1921, quando o professor da faculdade de Medicina e Farmácia de Bucareste Nicolae Paulescu isolou a insulina pela primeira vez. Desde 1916 o médico romeno estudava esse “líquido pancreático” (denominou-o de pancreína) que tinha um efeito normalizante nos níveis de açúcar do sangue em cães diabéticos. Em 1921, seu trabalho foi publicado na Seção Romena da Sociedade de Biologia de Paris que tinha três tópicos principais:</span></span><br /><div style="text-align: left;"><ul><li><span style="font-size:100%;"><span style="font-family:arial;">O efeito do extrato pancreático injetado em um animal diabético através do sangue;</span></span></li><li><span style="font-size:100%;"><span style="font-family:arial;">A influência do tempo decorrido da injeção pancreática intravenosa em um animal diabético;</span></span></li><li><span style="font-size:100%;"><span style="font-family:arial;">O efeito do extrato pancreático injetado em um animal normal através do sangue;</span></span></li></ul><span style="font-size:100%;"><span style="font-family:arial;">Seu trabalho foi muito importante (estando envolvido em uma polêmica do Nobel de 1923, que será mais bem explicada depois), pois abria um novo leque de informações para os pesquisadores subseqüentes, além de ser o descobridor da insulina. Entretanto, deve-se ressaltar que os méritos de Nicolae como descobridor da insulina só foram reconhecidos depois de 50 após a primeira patente de procedimento para produzir insulina. Nicolae também é lembrado por suas pesquisas na estrutura do baço e no mecanismo da febre.<br /><br /><br />Fonte: <a href="http://pt.wikipedia.org/wiki/Insulina">http://pt.wikipedia.org/wiki/Insulina</a><br /></span></span> </div>Pedro Cavalcantehttp://www.blogger.com/profile/15367908941105629332noreply@blogger.com0tag:blogger.com,1999:blog-6171084656970237216.post-1059051565161074042009-06-16T21:12:00.005-03:002009-07-02T23:45:28.987-03:00Primeiros Relatos - Experiência de Minkowski<a onblur="try {parent.deselectBloggerImageGracefully();} catch(e) {}" href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhVrSXEE3WipBRu3sbS7brEX_12nndN3VXuDyGmVCracQ5wlWigVzjEOiUF2aUANLLTr1cMIS267nwzOJgYtDChmZ4PYhHcZpaOZXivD_gw8kKBQXOSZuTtC_WPknfxGDAJVmX53qoR4I6J/s1600-h/pancreas.jpg"><img style="margin: 0pt 10px 10px 0pt; float: left; cursor: pointer; width: 320px; height: 215px;" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhVrSXEE3WipBRu3sbS7brEX_12nndN3VXuDyGmVCracQ5wlWigVzjEOiUF2aUANLLTr1cMIS267nwzOJgYtDChmZ4PYhHcZpaOZXivD_gw8kKBQXOSZuTtC_WPknfxGDAJVmX53qoR4I6J/s320/pancreas.jpg" alt="" id="BLOGGER_PHOTO_ID_5348083166215773282" border="0" /></a>
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mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0cm; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} </style> <![endif]--><span style=";font-family:arial;font-size:100%;" ><span style="line-height: 115%; color: rgb(0, 0, 0);font-size:12px;" ><span style="font-size:100%;">O </span><span style="font-size:100%;">pr</span><span style="font-size:100%;">imeiro relato da insulina foi dado em 1889 por dois cientistas alemães, Von Mering e Minkowski, que descobriram que o pâncreas produzia uma substância, ou hormônio, capaz de controlar o açúcar no sangue e evitar os sintomas do diabetes. (Lembrando que o conceito de hormônio só foi bem estabelecido depois por Ernest H. Starling).
<br />
<br />Fazendo experiências com animais</span> <span style="font-size:100%;">perceberam que o pâncreas de cachorros produzia um composto químico que se opunha ao diabetes. Sua experiência consistiu em remover o pâncreas de um cão a fim de averiguar se aquele órgão seria essencial à vida. Após a cirurgia, eles verificaram que o animal exibia os sintomas típicos da diabetes severa, incluindo poliúria com glicosúria, sede insaciável e hiperglicemia.</span><o:p></o:p></span><span style="color: rgb(0, 0, 0);"> </span></span><span style="line-height: 115%;font-family:";font-size:12;" ><span style="font-size:100%;"><span style="color: rgb(0, 0, 0);font-family:arial;" >Logo após esse experimento, diversos pesquisadores tentaram sem muito sucesso tratar o diabetes com a administração de extratos de pâncreas retirados de animais. Contudo, por aquela substância ainda não ser bem compreendida os tratamentos não eram eficazes. Essa história só teve uma reviravolta no início da década de 20, o que mudaria para melhor a vida dos pacientes que sofriam de diabetes.</span></span>
<br /><span style="font-size:100%;">
<br />Fonte: <a href="http://www.diabetes.org.br/aprendendo/historia/historiaprimeiros.php">http://www.diabetes.org.br/aprendendo/historia/historiaprimeiros.php</a></span>
<br /></span>Pedro Cavalcantehttp://www.blogger.com/profile/15367908941105629332noreply@blogger.com1tag:blogger.com,1999:blog-6171084656970237216.post-9535169964824095882009-06-16T14:30:00.001-03:002009-06-30T21:31:18.233-03:00Inaugurando...<span>A insulina, hormônio responsável pela regulação da glicemia no organismo (mais especificamente a redução da glicemia) começa a ser descrita em 1889, ainda que de forma precária. No referido ano, dois cientistas alemães, Von Mering e Minkowski, pesquisadores do Diabetes, descobriram que uma substância que era produzida no pâncreas tinha a capacidade de controlar o açúcar no sangue e impedir os sintomas do Diabetes. Até então o termo hormônio não era empregado.</span><br /><br /><span>Até então, porém, a Insulina em si não havia sido descoberta, uma vez que não se tinha isolado essa substancia do pâncreas. A descoberta, que mais tarde renderia o premio Nobel em Medicina (1923) aos seus autores, se inicia no ano de 1922 e é concretizada pelos pesquisadores Banting, Best, Collip e MacLeod, na Universidade de Toronto.</span><br /><br /><span>A primeira injeção de insulina em humanos ocorreu em janeiro de 1922 em Leonard Thompson, que sofreu de certos efeitos colaterais provocados pela precária purificação da proteína. Após novas purificações e aplicações, a melhora e os resultados foram sentidos de forma significativa. Apesar de isso ter sido um avanço significativo no tratamento do diabetes, a expectativa de vida dos pacientes ainda era relativamente baixa e, portanto, o preparo de insulina necessitava de claras melhorias.</span>Wallace Stwart C. Padilhahttp://www.blogger.com/profile/07757751516224716512noreply@blogger.com0